tropoelastin allergan

Structure of the elastin gene and alternative splicing of elastin mRNA: implications for human disease. The cross-linking domains are enriched for either Lys-Pro (KP) or Lys-Ala (KA) motifs and form cross-links that link growing tropoelastin chains during elastogenesis; note that exon 6 encodes a KA domain. Co-author Professor Anthony Weiss from the Charles Perkins Centre and Faculty of Science explained: "Tropoelastin can repair the heart because it is a precise replica of the body's natural elastic protein,". The first successful experiments to define the 3D envelope of tropoelastin utilized small angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS) (Baldock et al., 2011). doi: 10.1016/j.jsb.2005.02.005, Martin, S. L., Vrhovski, B., and Weiss, A. S. (1995). Chem. Primary structure of porcine tropoelastin. Unsubstituted models are also critical to understanding self-assembly. Eur. doi: 10.1016/j.matbio.2006.10.002, Dyksterhuis, L. B., and Weiss, A. S. (2010). Tropoelastin is a spring-like molecule that is extremely extensible prior to cross-linking. Fibulin-4 and -5, but not fibulin-2, are associated with tropoelastin deposition in elastin-producing cell culture. Crosslinking [ edit] doi: 10.1111/febs.14929, Hinderer, S., Shena, N., Ringuette, L. J., Hansmann, J., Reinhardt, D. P., Brucker, S. Y., et al. Elastin synthesis and fiber assembly. 26, 125135. Recycling of the 67-kDa elastin binding protein in arterial myocytes is imperative for secretion of tropoelastin. Proc. Chem. Identification of an elastin cross-linking domain that joins three peptide chains. 26, 115124. We are making enrolling in text alerts easier than ever. Protein Eng. Chemistry 10, 31663176. 252, 351365. doi: 10.1016/j.matbio.2006.08.258, Clarke, A. W., Arnspang, E. C., Mithieux, S. M., Korkmaz, E., Braet, F., and Weiss, A. S. (2006). Detailed Description: Coarse-grained model of tropoelastin self-assembly into nascent fibrils. Allergan to acquire University of Sydney spinoff Elastagen For many years it was difficult to study tropoelastin at an atomic scale, but the application of computational methods, such as full-atomistic molecular dynamics and elastic network models, in combination with powerful low-resolution structural studies, have expanded the field and delivered an enhanced understanding of the mechanisms that contribute to self-assembly. After a period of collaboration with the Elastagen team, US biopharmaceutical giant Allergan acquired Elastagen in 2018 for over $350 million in total deal value. Biochemistry 45, 99899996. (2021). FEBS J. Biochim. 258, 118. Allergen Acquires Elastagen - pharmasalmanac.com Matrix Biol. Novel Recombinant Tropoelastin Implants Restore Skin - PubMed Cell Biol. Elastagen Pty Ltd, a clinical stage company developing medical device products based on recombinant tropoelastin, today announced that it has entered into a definitive agreement under which Allergan plc, a leading global biopharmaceutical company, has agreed to acquire Elastagen.

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